C10032796 / invoice 10000

HISTORY
Presented for neurofen ingestion- Stole packet of 24 (not whole packet- 4-5 tablets already gone. O found 14 complete tablets and some more left).  (up to 43mg/kg).

If ate all 10 (some powder left + pain relief). 

Meds: Pain relief tablet. 

    GI signs: >25 mg/kg
    Renal signs: >175 mg/kg
    CNS signs: >400 mg/kg


EXAM
HR 132bpm, no m/a
RR pant
Temp not taken
Abdomen soft and comfortable
MM pm, CRT <2s

ASSESSMENT
Nurofen ingestion- GI dose, not likely nephrotoxic

PLAN
Misoprostal BID for 3d
Discontinue pain relief meds
Offered renals. O declined. 

COMMUNICATION
Revisit if V+, lethargic or not eating. 

O presented due to ingestion of ant bait (containing fipronil). 
Informed O to call animal poisons (response below) as do not believe this is a toxic dose. 
O left without consult after discussion with animal poisons. 

In Beagle dogs, short term oral toxicity studies also reported toxic effects at the higher dose rates
used, particularly 10 mg/kg/d for 13 weeks where neurological and gastrointestinal signs were
observed (Holmes, 1991b). The NOAEL was 0.5 mg/kg/day. Oral administration of fipronil for
one year revealed neurological signs when higher dose rates were administered (> 1 mg/kg/d) and a
NOAEL of between 0.2-0.3 mg/kg/d by oral administration was calculated for the dog (Holmes,
1992, 1993). Since one female dog did exhibit possible neurological signs (over-activity) when
dosed at 0.2 mg/kg/d, a “safe” daily dose of fipronil may be less than this suggested NOAEL.